An electrostatic basis for the stability of thermophilic proteins.

@article{Dominy2004AnEB,
  title={An electrostatic basis for the stability of thermophilic proteins.},
  author={Brian N. Dominy and Herv{\'e} Minoux and Charles L. Brooks},
  journal={Proteins},
  year={2004},
  volume={57 1},
  pages={128-41}
}
Two factors provide key contributions to the stability of thermophilic proteins relative to their mesophilic homologues: electrostatic interactions of charged residues in the folded state and the dielectric response of the folded protein. The dielectric response for proteins in a "thermophilic series" globally modulates the thermal stability of its members, with the calculated dielectric constant for the protein increasing from mesophiles to hyperthermophiles. This variability results from… CONTINUE READING

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