An electrophysiological study of the mechanism of fatigue in multiple sclerosis.

@article{Sheean1997AnES,
  title={An electrophysiological study of the mechanism of fatigue in multiple sclerosis.},
  author={Geoffrey L Sheean and Nicholas M F Murray and John C. Rothwell and David H. Miller and Alan J. Thompson},
  journal={Brain : a journal of neurology},
  year={1997},
  volume={120 ( Pt 2)},
  pages={299-315}
}
Fatigue is a common and disabling symptom in multiple sclerosis but is poorly understood. We investigated 'physiological' fatigue in 21 patients with multiple sclerosis who complained of disabling fatigue by measuring the decline in strength during a 45 s maximal contraction of the adductor pollicis muscle. The results were compared with those from a control group of 19 healthy subjects. The strength of control subjects declined by approximately 20% during the contraction; twitch interpolation… CONTINUE READING