An electron microscope study of the relative positions of the 4S and ribosomal RNA genes in HeLa cell mitochondrial DNA

@article{Angerer1976AnEM,
  title={An electron microscope study of the relative positions of the 4S and ribosomal RNA genes in HeLa cell mitochondrial DNA},
  author={Lynne M. Angerer and Norman Davidson and William Murphy and Dennis Lynch and Giuseppe Attardi},
  journal={Cell},
  year={1976},
  volume={9},
  pages={81-90}
}

DNA electron microscopy.

  • C. Brack
  • Biology, Chemistry
    CRC critical reviews in biochemistry
  • 1981
DNA electron microscopy techniques developed with the aim of studying the structural and functional organization of genetic material have become a prerequisite for determining regions of interest for subsequent nucleotide sequencing.
...

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The avidin-biotin complex in electron microscopy seems especially appropriate for seqential staining procedures, as well as for visualization of reaction sites of biotin-labeled, low-molecular-weight reagents.