An electrogenic proton-translocating adenosine triphosphatase from bovine kidney medulla.

@article{Gluck1984AnEP,
  title={An electrogenic proton-translocating adenosine triphosphatase from bovine kidney medulla.},
  author={Stephen Gluck and Qais Al-Awqati},
  journal={The Journal of clinical investigation},
  year={1984},
  volume={73 6},
  pages={
          1704-10
        }
}
Urinary acidification in the mammalian collecting tubule is similar to that in the turtle bladder, an epithelium whose H+ secretion is due to a luminal proton-translocating ATPase. We isolated a fraction from bovine renal medulla, which contains ATP-dependent proton transport. H+ transport was found to be electrogenic in that its rate was reduced by a membrane potential. H+ transport activity was inhibited by N-ethyl maleimide and dicyclohexyl carbodiimide, but not by oligomycin or vanadate… CONTINUE READING

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