An electrochemiluminescence assay for analysis of rabies virus glycoprotein content in rabies vaccines.

@article{Smith2013AnEA,
  title={An electrochemiluminescence assay for analysis of rabies virus glycoprotein content in rabies vaccines.},
  author={Todd G. Smith and John Anthony Ellison and Xiaoyue Ma and Natalia A Kuzmina and William C. Carson and Charles E. Rupprecht},
  journal={Vaccine},
  year={2013},
  volume={31 33},
  pages={
          3333-8
        }
}
Vaccine potency testing is necessary to evaluate the immunogenicity of inactivated rabies virus (RABV) vaccine preparations before human or veterinary application. Currently, the NIH test is recommended by the WHO expert committee to evaluate RABV vaccine potency. However, numerous disadvantages are inherent concerning cost, number of animals and biosafety requirements. As such, several in vitro methods have been proposed for the evaluation of vaccines based on RABV glycoprotein (G) quality and… CONTINUE READING

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