An electrochemical platform for acetylcholinesterase activity assay and inhibitors screening based on Michael addition reaction between thiocholine and catechol-terminated SAMs.

Abstract

An electrochemical platform for acetylcholinesterase (AChE) activity assay and its inhibitors screening is developed based on the Michael addition reaction of thiocholine, the hydrolysis product of acetylthiocholine (AsCh) in the presence of AChE, with the electrogenerated o-quinone of catechol-terminated SAMs on a gold electrode. For understanding and… (More)
DOI: 10.1039/c1an15601b

Topics

Cite this paper

@article{Tian2011AnEP, title={An electrochemical platform for acetylcholinesterase activity assay and inhibitors screening based on Michael addition reaction between thiocholine and catechol-terminated SAMs.}, author={Yuan Tian and Siqiu Ye and Xinhao Shi and Li Jing and Cong Liang and Yuezhong Xian}, journal={The Analyst}, year={2011}, volume={136 23}, pages={5084-90} }