An electrochemical mass sensor for diagnosing diabetes in human serum.

@article{Singh2014AnEM,
  title={An electrochemical mass sensor for diagnosing diabetes in human serum.},
  author={Vini Singh and Sadagopan Krishnan},
  journal={The Analyst},
  year={2014},
  volume={139 4},
  pages={
          724-8
        }
}
An electrochemical mass sensor for clinically relevant detection of insulin in human serum conjugated to magnetic nanoparticles and captured onto antibody immobilized gold coated quartz resonators is reported for the first time. 
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References

SHOWING 1-10 OF 41 REFERENCES
Ultrasensitive label free electrical detection of insulin in neat blood serum.
TLDR
The development, and clinical application, of a highly sensitive and selective electrical insulin biosensor based on a chemisorbed zwittorionic polymer support and a novel reagentless sensing technique based on phase monitoring electrochemical impedance spectroscopy is reported.
Enzyme immunoassay of insulin at picomolar levels based on the coulometric determination of hydrogen peroxide
Magnetic particle-based ultrasensitive biosensors for diagnostics
TLDR
This article highlights some of the most recent developments, with a focus on MP-based ultrasensitive assays that use an antibody or aptamer as the target-binding agent, and that utilize efficient signal amplification/readout strategies.
Imprinting molecular recognition sites on multiwalled carbon nanotubes surface for electrochemical detection of insulin in real samples
Attomolar detection of a cancer biomarker protein in serum by surface plasmon resonance using superparamagnetic particle labels.
TLDR
It is shown for the first time that clustering of superparamagnetic labels on SPR surfaces leads to unprecedented sensitivity and ultralow DL for protein biomarkers in serum for cancer biomarker prostate specific antigen in serum.
Needle-type dual microsensor for the simultaneous monitoring of glucose and insulin.
TLDR
A miniature needle-type sensor suitable for the simultaneous amperometric monitoring of glucose and insulin is described, which holds great promise for real-time measurements of the insulin/glucose ratio and for improved management of diabetes.
Electrochemical detection of trace insulin at carbon-nanotube-modified electrodes
Fabrication of a Sensitive Cholesterol Biosensor Based on Cobalt‐oxide Nanostructures Electrodeposited onto Glassy Carbon Electrode
Electrodeposited cobalt oxide (CoOx) nanomaterials are not only used for immobilization of cholesterol oxidase (ChOx) but also as electron transfer mediator for oxidation of H2O2 generated in the…
Magnetic particles in ultrasensitive biomarker protein measurements for cancer detection and monitoring.
TLDR
The review covers applications of magnetic particles in protein immunoassays in emerging research and commercial methods, and stresses multiplexed protein assays for reliable future cancer diagnostics.
Picomolar detection of insulin at renewable nickel powder-doped carbon composite electrode.
TLDR
Sensitivity, detection limit, and antifouling properties of this insulin sensor are better than all of the reports in the literature.
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