An elastomeric patch derived from poly(glycerol sebacate) for delivery of embryonic stem cells to the heart.

@article{Chen2010AnEP,
  title={An elastomeric patch derived from poly(glycerol sebacate) for delivery of embryonic stem cells to the heart.},
  author={Q Y Chen and Hikaru Ishii and George A. Thouas and Alexander R Lyon and Jamie S. Wright and Jonny James Blaker and Wojciech Chrzanowski and Aldo R Boccaccini and Nadire N. Ali and Jonathan C Knowles and Sian E Harding},
  journal={Biomaterials},
  year={2010},
  volume={31 14},
  pages={3885-93}
}
We hypothesize that a combinatorial approach of ventricle constraint and stem cell therapy would offer a greater benefit for the treatment of heart failure than either strategy alone. A heart patch would serve two therapeutic purposes: biomechanical support and cell delivery. In this study, we describe a hybrid heart patch engineered from a synthetic elastomer, poly(glycerol sebacate) (PGS), supplemented with cardiomyocytes differentiated from human embryonic stem cells (hESCs). In line with… CONTINUE READING