An elastic element in the protocadherin-15 tip link of the inner ear

@inproceedings{ArayaSecchi2016AnEE,
  title={An elastic element in the protocadherin-15 tip link of the inner ear},
  author={Raul Araya-Secchi and Brandon L Neel and Marcos Sotomayor},
  booktitle={Nature communications},
  year={2016}
}
Tip link filaments convey force and gate inner-ear hair-cell transduction channels to mediate perception of sound and head movements. Cadherin-23 and protocadherin-15 form tip links through a calcium-dependent interaction of their extracellular domains made of multiple extracellular cadherin (EC) repeats. These repeats are structurally similar, but not identical in sequence, often featuring linkers with conserved calcium-binding sites that confer mechanical strength to them. Here we present the… CONTINUE READING
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