An efficient synthesis of trisubstituted oxazoles via chemoselective O-acylations and intramolecular Wittig reactions.

Abstract

Preparation of new types of trisubstituted oxazoles is realized via chemoselective O-acylations and intramolecular Wittig reactions with ester functionalities using in situ formed phosphorus ylides as key intermediates. A plausible reaction mechanism for this undiscovered chemistry is also proposed based on the existence of expected and rearranged isomeric… (More)
DOI: 10.1039/c3cc45883k

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@article{Tsai2013AnES, title={An efficient synthesis of trisubstituted oxazoles via chemoselective O-acylations and intramolecular Wittig reactions.}, author={Yi-Ling Tsai and Yu-Shiou Fan and Chia-Jui Lee and Chan-Hui Huang and Utpal Kumar Das and Wenwei Lin}, journal={Chemical communications}, year={2013}, volume={49 87}, pages={10266-8} }