An efficient synthesis of (+/-)-frondosin B using a Stille-Heck reaction sequence.

Abstract

A concise, convergent synthesis of (+/-)-frondosin B has been developed based on the application of a Stille-Heck reaction sequence of 2-chloro-5-methoxybenzo[b]furan-3-yl triflate and 2-(3-butenyl)-3-(trimethylstannyl)cyclohex-2-enone giving the racemic natural product in a 34% overall yield. 
DOI: 10.1039/b924542a

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Cite this paper

@article{Masters2010AnES, title={An efficient synthesis of (+/-)-frondosin B using a Stille-Heck reaction sequence.}, author={K J Masters and Bernard L Flynn}, journal={Organic & biomolecular chemistry}, year={2010}, volume={8 6}, pages={1290-2} }