An efficient prebiotic synthesis of cytosine and uracil
@article{Robertson1995AnEP, title={An efficient prebiotic synthesis of cytosine and uracil}, author={M. P. Robertson and S. Miller}, journal={Nature}, year={1995}, volume={375}, pages={772-774} }
IN contrast to the purines13, the routes that have been proposed for the prebiotic synthesis of pyrimidines from simple precursors give only low yields. Cytosine can be synthesized from cyano-acetylene and cyanate4,5; the former precursor is produced from a spark discharge in a CH4/N2 mixture4,5 and is an abundant interstellar molecule6. But this reaction requires relatively high concentrations of cyanate (>0.1 M), which are unlikely to occur in aqueous media as cyanate is hydrolysed rapidly… CONTINUE READING
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References
SHOWING 1-10 OF 12 REFERENCES
Studies in prebiotic synthesis. 3. Synthesis of pyrimidines from cyanoacetylene and cyanate.
- Chemistry, Medicine
- Journal of molecular biology
- 1968
- 196
Studies in prebiotic synthesis. IV. Conversion of 4-aminoimidazole-5-carbonitrile derivatives to purines.
- Chemistry, Medicine
- Journal of molecular biology
- 1968
- 83
An all-purine precursor of nucleic acids.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1988
- 85
- PDF
Enzymatic incorporation of a new base pair into DNA and RNA extends the genetic alphabet
- Biology, Medicine
- Nature
- 1990
- 460
Chemical evolution. 18. Synthesis of pyrimidines from guanidine and cyanoacetaldehyde.
- Biology, Medicine
- Journal of molecular evolution
- 1974
- 50