An efficient multiple-exposure analysis of the toxicity of crisnatol, a DNA intercalator in phase II clinical trials

@article{Zucker1992AnEM,
  title={An efficient multiple-exposure analysis of the toxicity of crisnatol, a DNA intercalator in phase II clinical trials},
  author={Robert M Zucker and David J. Adams and Kenneth W. Bair and Kenneth H. Elstein},
  journal={Investigational New Drugs},
  year={1992},
  volume={10},
  pages={1-15}
}
To investigate the toxicity and mechanism of action of crisnatol (CRS), a new DNA intercalator currently in phase II clinical trials, we analyzed cellular and nuclear flow cytometric (FCM) parameters of murine erythroleukemic cells (MELC) exposed to a range of CRS concentrations over three exposure conditions: short-term (4 h), long-term (24 h), and short-term with recovery (4 h+/19 h−). At 0.5–1.0μM CRS, 4 h exposure results in a reversible G2-phase block, while 24 h exposure results in > G2… CONTINUE READING

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