An efficient method to limit microglia-dependent effects in astroglial cultures.

  title={An efficient method to limit microglia-dependent effects in astroglial cultures.},
  author={Sophie Losciuto and Gauthier Dorban and Sebastien Gabel and Audrey Gustin and Claire Hoenen and Luc Grandbarbe and Paul Heuschling and Tony Heurtaux},
  journal={Journal of neuroscience methods},
  volume={207 1},
Microglia, the CNS resident macrophages, and astrocytes, the most abundant glial cell population, are both implicated in brain pathologies and can exhibit a pro-inflammatory phenotype. Microglial cells are known to rapidly and strongly react to brain insults. They will promote astrocyte activation and may lead to a vicious, self-perpetuating cycle of chronic inflammation. To obtain a better understanding of the individual role of both cell types, primary cells are frequently used in in vitro… CONTINUE READING


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