An efficient method for one-pot synthesis of 3-alkoxy-substituted chromeno[4,3-b]pyrrol-4(1H)-one derivatives

@article{Yang2018AnEM,
  title={An efficient method for one-pot synthesis of 3-alkoxy-substituted chromeno[4,3-b]pyrrol-4(1H)-one derivatives},
  author={Xiaofeng Yang and Lei Jing and Zhiwei Chen},
  journal={Chemistry of Heterocyclic Compounds},
  year={2018},
  volume={54},
  pages={1065-1069}
}
A one-pot two-step reaction of 4-aminocoumarin with arylglyoxal monohydrates and p-toluenesulfonates has been developed, which offers 3-alkoxy-substituted chromeno[4,3-b]pyrrol-4(1H)-ones in moderate to good yields. At first, arylglyoxal monohydrates and 4-aminocoumarin were converted into 3-hydroxychromeno[4,3-b]pyrrol-4(1H)-one intermediates in AcOH under reflux. Then the title compounds in an in situ reaction of the intermediates with p-toluenesulfonates catalyzed by DBU in refluxing toluene… CONTINUE READING

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