An efficient high-throughput screening method for MYST family acetyltransferases, a new class of epigenetic drug targets.

@article{Falk2011AnEH,
  title={An efficient high-throughput screening method for MYST family acetyltransferases, a new class of epigenetic drug targets.},
  author={Hendrik Falk and Theresa Connor and Hong Yang and Karen J Loft and Joanne L Alcindor and George Nikolakopoulos and Regina N Surjadi and John D. Bentley and Meghan K. Hattarki and Olan Dolezal and James M Murphy and Brendon J. Monahan and Thomas S. Peat and Tim Thomas and Jonathan B. Baell and John P. Parisot and Ian P. Street},
  journal={Journal of biomolecular screening},
  year={2011},
  volume={16 10},
  pages={1196-205}
}
Epigenetic aberrations are increasingly regarded as key factors in cancer progression. Recently, deregulation of histone acetyltransferases (HATs) has been linked to several types of cancer. Monocytic leukemia zinc finger protein (MOZ) is a member of the MYST family of HATs, which regulate gene expression in cell proliferation and differentiation. Deregulation of these processes through constitutively active MOZ fusion proteins gives rise to the formation of leukemic stem cells, rendering MOZ… CONTINUE READING

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