An efficient gene transfer method mediated by ultrasound and microbubbles into the kidney.

@article{Koike2005AnEG,
  title={An efficient gene transfer method mediated by ultrasound and microbubbles into the kidney.},
  author={Hiromi Koike and N. Miyoshi-G. Tomita and Haruhito Azuma and Yoshiaki Taniyama and Keita Yamasaki and Yasuo Kunugiza and Katsuro Tachibana and Toshio Ogihara and Ryuichi Morishita},
  journal={The journal of gene medicine},
  year={2005},
  volume={7 1},
  pages={108-16}
}
BACKGROUND Safety issues are of paramount importance in clinical human gene therapy. From this point of view, it would be better to develop a novel non-viral efficient gene transfer method. Recently, it was reported that ultrasound exposure could induce cell membrane permeabilization and enhance gene expression. METHODS In this study, we examined the potential of ultrasound for gene transfer into the kidney. First, we transfected rat left kidney with luciferase plasmid mixed with microbubbles… CONTINUE READING

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