An efficient approach to isolate STAT regulated enhancers uncovers STAT92E fundamental role in Drosophila tracheal development

@inproceedings{Sotillos2010AnEA,
  title={An efficient approach to isolate STAT regulated enhancers uncovers STAT92E fundamental role in Drosophila tracheal development},
  author={Sol Sotillos and Jos{\'e} Manuel Espinosa-V{\'a}zquez and Filippo Foglia and Nan Hu and James Castelli-Gair Hombr{\'i}a},
  booktitle={Developmental biology},
  year={2010}
}
The ventral veinless (vvl) and trachealess (trh) genes are determinants of the Drosophila trachea. Early in development both genes are independently activated in the tracheal primordia by signals that are ill defined. Mutants blocking JAK/STAT signaling at any level do not form a tracheal tree suggesting that STAT92E may be an upstream transcriptional activator of the early trachea determinants. To test this hypothesis we have searched for STAT92E responsive enhancers activating the expression… CONTINUE READING

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Gramates L.S

  • 2007

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