An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice

@article{TraykovaBrauch2008AnEA,
  title={An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice},
  author={Milena Traykova-Brauch and K. Sch{\"o}nig and O. Greiner and Tewfik Miloud and A. Jauch and Manja Bode and D. Felsher and A. Glick and D. Kwiatkowski and H. Bujard and J. Horst and M. K. Doeberitz and F. Niggli and W. Kriz and H. Gr{\"o}ne and R. Koesters},
  journal={Nature Medicine},
  year={2008},
  volume={14},
  pages={979-984}
}
We describe a transgenic mouse line, Pax8-rtTA, which, under control of the mouse Pax8 promoter, directs high levels of expression of the reverse tetracycline–dependent transactivator (rtTA) to all proximal and distal tubules and the entire collecting duct system of both embryonic and adult kidneys. Using crosses of Pax8-rtTA mice with tetracycline-responsive c-MYC mice, we established a new, inducible model of polycystic kidney disease that can mimic adult onset and that shows progression to… Expand
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