An efficient and regiospecific strategy to N7-substituted purines and its application to a library of trisubstituted purines.

@article{Liu2006AnEA,
  title={An efficient and regiospecific strategy to N7-substituted purines and its application to a library of trisubstituted purines.},
  author={Jinglin Liu and Qun Dang and Zhonglin Wei and Fuqiang Shi and Xu Bai},
  journal={Journal of combinatorial chemistry},
  year={2006},
  volume={8 3},
  pages={410-6}
}
A regiospecific strategy for the preparation of N(7)-substituted purines in an efficient manner was devised. This approach to 6,7,8-trisubstituted purines relies on the cyclization reactions of suitably substituted pyrimidines (1) with either a carboxylic acid or an aldehyde. The method development for the five-step synthetic strategy outlined here was… CONTINUE READING