An efficient and information-rich biochemical method design for fragment library screening on ion channels.

Abstract

Drug discovery requires a simple, rapid, and cost-effective method for the early identification of novel leads and elimination of poor candidates. Here we present an experimental design that fulfils these criteria, using a ligand-gated ion channel expressed in a mammalian cell line, whose function can be probed using a voltage-sensitive dye. The… (More)
DOI: 10.2144/000113538

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