An efficient RNA-cleaving DNA enzyme that synchronizes catalysis with fluorescence signaling.

@article{Mei2003AnER,
  title={An efficient RNA-cleaving DNA enzyme that synchronizes catalysis with fluorescence signaling.},
  author={Shirley H J Mei and Zhongjie Liu and John D Brennan and Yingfu Li},
  journal={Journal of the American Chemical Society},
  year={2003},
  volume={125 2},
  pages={412-20}
}
DNA enzymes are single-stranded DNA molecules with catalytic capabilities that are isolated from random-sequence DNA libraries by "in vitro selection". This new class of catalytic biomolecules has the potential of being used as unique molecular tools in a variety of innovative applications. Here we describe the creation and characterization of an RNA-cleaving autocatalytic DNA, DEC22-18, that uniquely links chemical catalysis with real-time fluorescence signaling capability in the same molecule… CONTINUE READING

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