An efficient HPLC method for the analysis of isomeric purity of technetium-99m-exametazime and identity confirmation using LC-MS.

Abstract

99mTc-exametazime (99mTc-d,l-HMPAO, 99mTc-d,l-hexamethylpropyleneamine oxime) is a neutral rather unstable complex of short-lived 99mTc (t(1/2)=6 h) with the d,l-isomer (mixture of D,D- and L,L-isomers) of a bis-amine bis-oxime tetraligand. It is widely used for measurement of regional cerebral perfusion in nuclear medicine. The meso-isomer (D,L-form… (More)

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Cite this paper

@article{Vanderghinste2003AnEH, title={An efficient HPLC method for the analysis of isomeric purity of technetium-99m-exametazime and identity confirmation using LC-MS.}, author={Dominique Vanderghinste and M Van Eeckhoudt and Christelle Y Terwinghe and Luc J. M. Mortelmans and Guy Bormans and Alfons Verbruggen and Hubert P. Vanbilloen}, journal={Journal of pharmaceutical and biomedical analysis}, year={2003}, volume={32 4-5}, pages={679-85} }