An effective tumor-targeting strategy utilizing hypoxia-sensitive siRNA delivery system for improved anti-tumor outcome.

Abstract

UNLABELLED Hypoxia is a feature of most solid tumors, targeting hypoxia is considered as the best validated yet not extensively exploited strategy in cancer therapy. Here, we reported a novel tumor-targeting strategy using a hypoxia-sensitive siRNA delivery system. In the study, 2-nitroimidazole (NI), a hydrophobic component that can be converted to… (More)
DOI: 10.1016/j.actbio.2016.08.029

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Cite this paper

@article{Kang2016AnET, title={An effective tumor-targeting strategy utilizing hypoxia-sensitive siRNA delivery system for improved anti-tumor outcome.}, author={Lin Kang and Bo Fan and Ping Sun and Wei Huang and Mingji Jin and Qiming Wang and Zhong-gao Gao}, journal={Acta biomaterialia}, year={2016}, volume={44}, pages={341-54} }