An effective method for the discrimination of motional anisotropy and chemical exchange.

@article{Kneller2002AnEM,
  title={An effective method for the discrimination of motional anisotropy and chemical exchange.},
  author={Julie M Kneller and Min Lu and Clay Bracken},
  journal={Journal of the American Chemical Society},
  year={2002},
  volume={124 9},
  pages={1852-3}
}
Analysis of the ratio of transverse and longitudinal relaxation rates (R2/R1) is an approach commonly used for estimation of overall correlation time and identification of chemical exchange in biological macromolecules. However, this analysis fails to distinguish between chemical exchange and motional anisotropy. We describe a simple method for identifying chemical exchange and motional anisotropy using the product, R1R2. In the slow tumbling regime, the R1R2 product results in a constant value… CONTINUE READING

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