An effective immune-monitoring protocol based on gene expression profiles in the peripheral T-cell fraction reactive to graft antigens.

@article{Lim2012AnEI,
  title={An effective immune-monitoring protocol based on gene expression profiles in the peripheral T-cell fraction reactive to graft antigens.},
  author={Dong-Gyun Lim and Youn-Hee Park and Sung-Eun Kim and Eun-jung Jung and Seong-Hee Jeong and Hyangsin Lee and Su-Jin Shin and Chan-Sik Park and D Han and Song-Cheol Kim},
  journal={Transplantation},
  year={2012},
  volume={94 8},
  pages={802-8}
}
BACKGROUND The ability to induce tolerance, or at least minimize the need for immunosuppressive therapy, is a high priority in organ transplantation. Accomplishing this goal requires a novel method for determining when a patient has become tolerant to or is rejecting their graft. Here, we sought to develop an efficient monitoring protocol based on gene expression profiles of recipient T cells in murine skin and islet allograft models. METHODS Unlike previous studies, here, gene expression… CONTINUE READING