An effective approach by a chelate reaction in optimizing the setting process of strontium-incorporated calcium phosphate bone cement.

@article{Kuang2012AnEA,
  title={An effective approach by a chelate reaction in optimizing the setting process of strontium-incorporated calcium phosphate bone cement.},
  author={Guan-ming Kuang and Warren Yau and Wing Moon Raymond Lam and Jun Wu and K. Y. Chiu and William Weijia Lu and Haobo Pan},
  journal={Journal of biomedical materials research. Part B, Applied biomaterials},
  year={2012},
  volume={100 3},
  pages={
          778-87
        }
}
Strontium (Sr) plays a special role in enhancing the biological osteo-stimulation of calcium phosphate cement (CPC), not only increasing osteoblast-related gene expression and the alkaline phosphatase (ALP) activity of mesenchymal stem cells (MSCs), but also inhibiting the differentiation of osteoclasts. However, the incorporation of Sr unfortunately delays the setting of CPC and weakens its mechanical properties. The purpose of this study was to overcome the aforementioned problems by… CONTINUE READING
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