An effective COVID-19 response in South America: the Uruguayan Conundrum

@article{Moreno2020AnEC,
  title={An effective COVID-19 response in South America: the Uruguayan Conundrum},
  author={Pilar Moreno and Gonzalo Moratorio and Gregorio Iraola and {\'A}lvaro Fajardo and Fabi{\'a}n Aldunate and Marianoel Pereira-G{\'o}mez and Paula Perbolianachis and Alicia Cost{\'a}bile and Fernando L{\'o}pez-Tort and Diego Sim{\'o}n and Cecilia Salazar and Ignacio Ferr{\'e}s and Florencia D{\'i}az-Viraqu{\'e} and Andr{\'e}s Abin and Mariana Bresque and Mat{\'i}as Fabregat and Mat{\'i}as Maidana and Bernardina Rivera and Mar{\'i}a Elena Cruces and Jorge Rodr{\'i}guez-Duarte and Paola Scavone and Miguel Angel Alegretti and Adriana Nab{\'o}n and Gustavo Gagliano and Raquel Isamara Le{\'o}n de la Rosa and Eduardo Henderson and Estela Bidegain and Leticia Zarantonelli and Vanesa Piattoni and Gonzalo Greif and Mar{\'i}a E. Francia and Carlos Robello and Rosario Dur{\'a}n and Gustavo Andr{\'e} Pereira de Brito and Victoria Bonnecarr{\`e}re and Miguel Sierra and Rodney Colina and M{\'o}nica Mar{\'i}n and Juan Cristina and R. Ehrlich and Fernando Paganini and Henry Cohen and Rafael Radi and Luis Barbeito and Jos{\'e} L. Badano and Otto Pritsch and Cecilia Fern{\'a}ndez and Rodrigo Arim and Carlos Batthy{\'a}ny},
  journal={medRxiv},
  year={2020}
}
Background: South America has become the new epicenter of the COVID-19 pandemic with more than 1.1M reported cases and >50,000 deaths (June 2020). Conversely, Uruguay stands out as an outlier managing this health crisis with remarkable success. Methods: We developed a molecular diagnostic test to detect SARS-CoV-2. This methodology was transferred to research institutes, public hospitals and academic laboratories all around the country, creating a COVID-19 diagnostic lab network. Uruguay also… 
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References

SHOWING 1-10 OF 21 REFERENCES
Opinion: What models can and cannot tell us about COVID-19
TLDR
Carefully delineating models’ strengths and shortcomings will not only clarify how they can help but also temper expectations among policymakers and members of the public looking to understand the full impact of the virus in the weeks and months ahead.
A New Framework and Software to Estimate Time-Varying Reproduction Numbers During Epidemics
TLDR
This tool produces novel, statistically robust analytical estimates of R that incorporates uncertainty in the distribution of the serial interval and should help epidemiologists quantify temporal changes in the transmission intensity of future epidemics by using surveillance data.
Serial Interval of COVID-19 among Publicly Reported Confirmed Cases
TLDR
This work estimates the distribution of serial intervals for 468 confirmed cases of coronavirus disease reported in China as of February 8, 2020 and finds that 12.6% of case reports indicated presymptomatic transmission.
Nextstrain: real-time tracking of pathogen evolution
TLDR
Nextstrain consists of a database of viral genomes, a bioinformatics pipeline for phylodynamics analysis, and an interactive visualization platform that presents a real-time view into the evolution and spread of a range of viral pathogens of high public health importance.
The mathematical strategy that could transform coronavirus testing
Four charts show how pooling samples from many people can save time or resources. Four charts show how pooling samples from many people can save time or resources.
IQ-TREE: A Fast and Effective Stochastic Algorithm for Estimating Maximum-Likelihood Phylogenies
TLDR
It is shown that a combination of hill-climbing approaches and a stochastic perturbation method can be time-efficiently implemented and found higher likelihoods between 62.2% and 87.1% of the studied alignments, thus efficiently exploring the tree-space.
MAFFT version 5: improvement in accuracy of multiple sequence alignment
TLDR
Improvement in accuracy was generally observed for most methods, but remarkably large for the new options of MAFFT proposed here, which showed higher accuracy than currently available methods including TCoffee version 2 and CLUSTAL W in benchmark tests consisting of alignments of >50 sequences.
R: A language and environment for statistical computing.
Copyright (©) 1999–2012 R Foundation for Statistical Computing. Permission is granted to make and distribute verbatim copies of this manual provided the copyright notice and this permission notice
Dates and Times Made Easy with lubridate
TLDR
The lubridate package for R is presented, which facilitates working with dates and times and introduces a conceptual framework for arithmetic with date-times in R.
...
1
2
3
...