An ectopic stromal implant model for hematopoietic reconstitution and in vivo evaluation of bone marrow niches.

Abstract

In adults, hematopoiesis takes places in the bone marrow, where specialized niches containing mesenchymal nonhematopoietic cells (stroma) harbor the hematopoietic stem cell (HSC). These niches are responsible and essential for the maintenance of HSCs. Attempts to expand HSCs fail to keep the general properties of stem cells, which depend on several niche… (More)
DOI: 10.3727/096368912X636993

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Cite this paper

@article{ParaguassBraga2012AnES, title={An ectopic stromal implant model for hematopoietic reconstitution and in vivo evaluation of bone marrow niches.}, author={Fl{\'a}vio Henrique Paraguass{\'u}-Braga and Ana Paula Greg{\'o}rio Alves and Isabella Maria Alvim Andrade Santos and Martin Bonamino and Adriana Bonomo}, journal={Cell transplantation}, year={2012}, volume={21 12}, pages={2677-88} }