An ectopic approach for engineering a vascularized tracheal substitute.

  title={An ectopic approach for engineering a vascularized tracheal substitute.},
  author={C. D. Tsao and Chao-Yin Ko and Shu-Rui Yang and Chin-Yu Yang and Eric M. Brey and Simon Huang and I -M. Chu and M. Cheng},
  volume={35 4},
Tissue engineering can provide alternatives to current methods for tracheal reconstruction. Here we describe an approach for ectopic engineering of vascularized trachea based on the implantation of co-cultured scaffolds surrounded by a muscle flap. Poly(L-lactic-co-glycolic acid) (PLGA) or poly(ε-caprolactone) (PCL) scaffolds were seeded with chondrocytes, bone marrow stem cells and co-cultured both cells respectively (8 groups), wrapped in a pedicled muscle flap, placed as an ectopic culture… CONTINUE READING


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