An early loss in membrane protein kinase C activity precedes the excitatory amino acid-induced death of primary cortical neurons.

@article{Durkin1996AnEL,
  title={An early loss in membrane protein kinase C activity precedes the excitatory amino acid-induced death of primary cortical neurons.},
  author={Jon P. Durkin and Richard Tremblay and Alastair M Buchan and James C. Blosser and B. S. Sheshadri Chakravarthy and Geoffrey A. R. Mealing and Patricia Morley and Dekun Song},
  journal={Journal of neurochemistry},
  year={1996},
  volume={66 3},
  pages={
          951-62
        }
}
Several lines of evidence indicate that a rapid loss of protein kinase C (PKC) activity may be important in the delayed death of neurons following cerebral ischemia. However, in primary neuronal cultures, cytotoxic levels of glutamate have been reported not to cause a loss in PKC as measured by immunoblot and conventional activity methods. This apparent contradiction has not been adequately addressed. In this study, the effects of cytotoxic levels of glutamate, NMDA, and alpha-amino-3-hydroxy-5… CONTINUE READING
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