An early increase in the disialoganglioside GD3 contributes to the development of neuronal apoptosis in culture


We induced apoptosis in primary cultures of cerebellar granule neurons by switching the growing medium into a medium containing lower concentrations of K+ (5 or 10 mM instead of 25 mM) or, alternatively, by addition of staurosporine. The apoptotic phenotype was always preceded by an early increase in the intracellular levels of the disialoganglioside GD3… (More)
DOI: 10.1038/sj.cdd.4401020


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