An early effect of aflatoxin B1 administered in vivo on the growth of bone marrow CFU-GM and the production of some cytokines in rats

@article{Cukrov1992AnEE,
  title={An early effect of aflatoxin B1 administered in vivo on the growth of bone marrow CFU-GM and the production of some cytokines in rats},
  author={Vera Cukrov{\'a} and Nobuyuki Kurita and Masaki Akao},
  journal={Mycopathologia},
  year={1992},
  volume={120},
  pages={113-119}
}
Our data demonstrate the granulopoietic toxicity of aflatoxin B1 (AFB1)in vivo and show an impact of this mycotoxin on the production of some humoral regulatory factors dealing with the granulopoietic developmental pathway (CSA, IL-1, IL-2). The dose of AFB1 studied represented approximately 1/5 of LD50 for young male rats. An early suppressive effect of… CONTINUE READING