An early decrease in Notch activation is required for human TCR-alphabeta lineage differentiation at the expense of TCR-gammadelta T cells.

@article{Walle2009AnED,
  title={An early decrease in Notch activation is required for human TCR-alphabeta lineage differentiation at the expense of TCR-gammadelta T cells.},
  author={Inge van De Walle and Greet De Smet and Magda de Smedt and Bart Vandekerckhove and Georges Leclercq and Jean Plum and Tom Taghon},
  journal={Blood},
  year={2009},
  volume={113 13},
  pages={2988-98}
}
Although well characterized in the mouse, the role of Notch signaling in the human T-cell receptor alphabeta (TCR-alphabeta) versus TCR-gammadelta lineage decision is still unclear. Although it is clear in the mouse that TCR-gammadelta development is less Notch dependent compared with TCR-alphabeta differentiation, retroviral overexpression studies in human have suggested an opposing role for Notch during human T-cell development. Using the OP9-coculture system, we demonstrate that changes in… CONTINUE READING