An early complement-dependent and TLR-4-independent phase in the pathogenesis of ethanol-induced liver injury in mice.

@article{Roychowdhury2009AnEC,
  title={An early complement-dependent and TLR-4-independent phase in the pathogenesis of ethanol-induced liver injury in mice.},
  author={Sanjoy Roychowdhury and Megan R. McMullen and Michele T Pritchard and Amy G Hise and Nico Van Rooijen and M. Edward Medof and Abram B. Stavitsky and Laura E Nagy},
  journal={Hepatology},
  year={2009},
  volume={49 4},
  pages={
          1326-34
        }
}
UNLABELLED The innate immune system has been implicated in the pathogenesis of alcoholic liver disease. Although innate immunity is usually considered an early response to injury, previous work implicating innate immunity in ethanol-induced liver injury focuses primarily on long-term ethanol exposure. We investigated the early period of ethanol exposure to determine whether there were temporal associations between activation of innate immune responses and known correlates of liver injury… CONTINUE READING

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