An eQTL analysis of the human glioblastoma multiforme genome.

  title={An eQTL analysis of the human glioblastoma multiforme genome.},
  author={Max Shpak and Amelia Weber Hall and Marcus M Goldberg and Dakota Z. Derryberry and Yunyun Y Ni and Vishwanath R. Iyer and Matthew C. Cowperthwaite},
  volume={103 4},
In this paper we use eQTL mapping to identify associations between gene dysregulation and single nucleotide polymorphism (SNP) genotypes in glioblastoma multiforme (GBM). A set of 532,954 SNPs was evaluated as predictors of the expression levels of 22,279 expression probes. We identified SNPs associated with fold change in expression level rather than raw expression levels in the tumor. Following adjustment for false discovery rate, the complete set of probes yielded 9257 significant… CONTINUE READING
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