An auxotrophic live oral Shigella flexneri vaccine: development and testing.

Abstract

Through transduction, a wild-type strain of Shigella flexneri serotype Y (SFL1) was rendered auxotrophic and dependent on aromatic metabolites that are not available in mammalian tissues. Monkeys that were orally vaccinated with 10(11) bacteria of the transductant strain SFL114 remained healthy when challenged with 10(11) bacteria of wild-type strains of S… (More)

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Cite this paper

@article{Krnell1991AnAL, title={An auxotrophic live oral Shigella flexneri vaccine: development and testing.}, author={Anders K{\"a}rnell and Bruce A. D. Stocker and Saori Katakura and H Sweiha and Finn Per Reinholt and Phung Dac Cam and Dang Duc Trach and Aron Lindberg}, journal={Reviews of infectious diseases}, year={1991}, volume={13 Suppl 4}, pages={S357-61} }