An autosomal genomic scan for loci linked to plasma leptin concentration in Pima Indians

@article{Walder2000AnAG,
  title={An autosomal genomic scan for loci linked to plasma leptin concentration in Pima Indians},
  author={K. Walder and Robert L. Hanson and Sayuko Kobes and W C Knowler and Eric Ravussin},
  journal={International Journal of Obesity},
  year={2000},
  volume={24},
  pages={559-565}
}
OBJECTIVE: To identify chromosomal regions linked to plasma leptin concentrations.DESIGN: Autosomal genome-wide scan, including 516 microsatellite markers. Sib-pair (Haseman–Elston) and variance components methods were used to assess genetic linkage.SUBJECTS: 770 Pima Indians comprising 239 nuclear families (for a total of 1199 sibling-pairs).MEASUREMENTS: Plasma leptin concentrations and body mass index (BMI), adjusted for age and sex.RESULTS: The strongest evidence for linkage with plasma… CONTINUE READING
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Is there appetite after GLP-1 and PACAP?

Annals of the New York Academy of Sciences • 1998

Signi®cance levels in complex inheritance

NE Morton
Am J Hum Genet • 1998