An autoradiographic study of the organization of intrahippocampal association pathways in the rat

@article{Swanson1978AnAS,
  title={An autoradiographic study of the organization of intrahippocampal association pathways in the rat},
  author={Larry W. Swanson and J. Michael Wyss and William M. Cowan},
  journal={Journal of Comparative Neurology},
  year={1978},
  volume={181}
}
The longer associational connections of the hippocampal formation have been studied autoradiographically in a series of adult rats after small injections of 3H‐amino acids into each of its various cytoarchitectonic fields. The major findings can be summarized as follows. The dentate gyrus projects in a topographically ordered manner upon the pyramidal cells of the regio inferior by way of the supra‐ and infrapyramidal bundles of mossy fibers. Certain cells in the hilar region of the dentate… 
An autoradiographic study of the efferent connections of the entorhinal cortex in the rat.
  • J. M. Wyss
  • Biology
    The Journal of comparative neurology
  • 1981
The longer connections of the entorhinal cortex have been studied autoradiographically in a series of rats, each of which received a small injection of 3H-amino acids in one of the various
Changes in the associational afferents to the dentate gyrus in the absence of its commissural input
TLDR
Findings suggest that in the absence of commissural afferents, the associational fibers are distributed more-or-less uniformly throughout the “hippocampal zone” of the molecular layer.
Evidence for the sprouting of the associational fibers to the dentate gyrus following removal of the commissural afferents in adult rats
TLDR
Observations make it clear that even in adult animals the associational fibers are capable of reactive synaptogenesis in response to the removal of the commissural afferents.
A quantitative EM autoradiographic study of the commissural and associational connections of the dentate gyrus in the rat
TLDR
Estimates of the relative numbers of grains within the peak region of labeling over the molecular layer of the supra- and infrapyramidal blades in the LM and EM autoradiographs are surprisingly close despite appreciable differences in the absolute number of grains in different experiments, suggesting that in selected systems grain density estimates of this type can provide an accurate indication of therelative numbers of axons and axon terminals derived from the labeled projection systems.
Intrinsic connections of the macaque monkey hippocampal formation: I. Dentate gyrus
TLDR
The topographic organization of the intrinsic connections of the monkey dentate gyrus is largely similar to that of the rat, and has the potential for integrating information across much of the rostrocaudal extent of the dentates gyrus.
Evidence for the sprouting of entorhinal afferents into the “hippocampal zone” of the molecular layer of the dentate gyrus
TLDR
The results suggest that there is no special barrier to the growth of entorhinal fibers and that the inner part of molecular layer of the dentate gyrus is capable of receiving afferents other than those normally present.
Evidence for an input to the molecular layer and the stratum granulosum of the dentate gyrus from the supramammillary region of the hypothalamus
SummaryInjections of a mixture of tritiated amino acids were made into the posterior hypothalamus in a series of rats and cats. In every case in which the injection involved a significant proportion
A golgi study of cell types in the hilar region of the hippocampus in the rat
  • D. Amaral
  • Biology
    The Journal of comparative neurology
  • 1978
TLDR
The results of the present study do not support the proposition that the deep hilar region is an extension of the pyramidal layer of the hippocampus as suggested by Lorente de Nó ('34), and thus CA4 is a misnomer.
The time of origin of neurons in Ammon's horn and the associated retrohippocampal fields
TLDR
The time of origin of the neurons in the hilus of the dentate gyrus, in the regio superior and regio inferior of Ammon's horn, and in the following retrohippocampal fields, has been determined in the rat by the technique of 3H-thymidine autoradiography.
Organization of intrahippocampal projections originating from CA3 pyramidal cells in the rat
TLDR
The distribution of intrahippocampal projections arising from the CA3 region of the rat hippocampus was investigated using in vitro and in vivo methods and bore numerous varicosities that electron microscopy confirmed to be presynaptic boutons.
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An autoradiographic study of the organization of the efferet connections of the hippocampal formation in the rat
The efferent connections of the hippocampal formation of the rat have been re‐examined autoradiographically following the injection of small quantities of 3H‐amino acids (usually 3H‐proline) into
An autoradiographic study of the commissural and ipsilateral hippocampo‐dentate projections in the adult rat
The distribution of the associational and commissural afferents to the inner one‐fourth of the molecular layer of the dentate gyrus of the rat, has been studied autoradiographically following small
A golgi study of cell types in the hilar region of the hippocampus in the rat
  • D. Amaral
  • Biology
    The Journal of comparative neurology
  • 1978
TLDR
The results of the present study do not support the proposition that the deep hilar region is an extension of the pyramidal layer of the hippocampus as suggested by Lorente de Nó ('34), and thus CA4 is a misnomer.
Origin and termination of the hippocampal perforant path in the rat studied by silver impregnation
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A detailed study of the origin and termination of the so‐called perforant path of the hippocampal region has been made in the rat, finding the origin to be in the medial part of the entorhinal area, from the most dorsal to the most ventral levels.
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The endings of the axons of the granule cells of the dentate fascia in relation to Lorente de Nó's areas CA3 and CA41 of Ammon's horn have certain special morphological characteristics described by Cajal2, who termed them mossy fibres, analogous to those of the cerebellum.
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TLDR
An autoradiographic study of the subcortical projections of the rat hippocampal formation shows that the efferent fibers of the hippocampus proper do not project to the hypothalamus but are confined to the precommissural fornix, ending primarily in the septum.
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