An autoradiographic study of the commissural and ipsilateral hippocampo‐dentate projections in the adult rat

@article{Fricke1978AnAS,
  title={An autoradiographic study of the commissural and ipsilateral hippocampo‐dentate projections in the adult rat},
  author={Russell A. Fricke and William M. Cowan},
  journal={Journal of Comparative Neurology},
  year={1978},
  volume={181}
}
  • R. Fricke, W. Cowan
  • Published 15 September 1978
  • Biology
  • Journal of Comparative Neurology
The distribution of the associational and commissural afferents to the inner one‐fourth of the molecular layer of the dentate gyrus of the rat, has been studied autoradiographically following small injections of 3H‐proline into the hilar region of the dentate (from which both groups of afferents arise). Different patterns of axonal labeling are observed after injections into the temporal (i.e., caudal), middle, or septal (rostral) thirds of the hippocampus. Thus after temporal injections… 
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TLDR
Findings suggest that in the absence of commissural afferents, the associational fibers are distributed more-or-less uniformly throughout the “hippocampal zone” of the molecular layer.
A quantitative EM autoradiographic study of the commissural and associational connections of the dentate gyrus in the rat
TLDR
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TLDR
The commissural connections of the hippocampal formation have been analyzed in the monkey using both anterograde and retrograde labeling techniques and a number of striking differences are observed.
Evidence for the sprouting of the associational fibers to the dentate gyrus following removal of the commissural afferents in adult rats
TLDR
Observations make it clear that even in adult animals the associational fibers are capable of reactive synaptogenesis in response to the removal of the commissural afferents.
An autoradiographic study of the organization of intrahippocampal association pathways in the rat
The longer associational connections of the hippocampal formation have been studied autoradiographically in a series of adult rats after small injections of 3H‐amino acids into each of its various
Evidence for an input to the molecular layer and the stratum granulosum of the dentate gyrus from the supramammillary region of the hypothalamus
SummaryInjections of a mixture of tritiated amino acids were made into the posterior hypothalamus in a series of rats and cats. In every case in which the injection involved a significant proportion
Evidence for the sprouting of entorhinal afferents into the “hippocampal zone” of the molecular layer of the dentate gyrus
TLDR
The results suggest that there is no special barrier to the growth of entorhinal fibers and that the inner part of molecular layer of the dentate gyrus is capable of receiving afferents other than those normally present.
Intrinsic connections of the macaque monkey hippocampal formation: I. Dentate gyrus
TLDR
The topographic organization of the intrinsic connections of the monkey dentate gyrus is largely similar to that of the rat, and has the potential for integrating information across much of the rostrocaudal extent of the dentates gyrus.
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TLDR
The characteristic adult pattern of distribution of the terminals of the two hippocampo‐dentate pathways is established, and although this pattern is best accounted for on the basis of a temporal competition for the available synaptic sites on the proximal parts of the dendrites of the granule cells, the spatial segregation of these two fiber systems from those arising in the entorhinal cortex, is probably due to the selective fasciculation of fibers in each group of afferents.
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TLDR
An ipsilateral pathway to the commissural zone of the dentate fascia has been demonstrated in the rat using the Fink‐Heimer silver impregnation method and the resulting degeneration was shown to be of purely ipsilaterally origin.
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  • Biology
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The afferent projections from the olfactory bulb and the prepiriform cortex have been studied in the rat using the autoradiographic method for demonstrating axonal connections, and the cytoarchitectonic characteristics of these areas have been described.
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