An autoradiographic study of dextromethorphan high-affinity binding sites in rat brain: sodium-dependency and colocalization with paroxetine.

@article{Meoni1997AnAS,
  title={An autoradiographic study of dextromethorphan high-affinity binding sites in rat brain: sodium-dependency and colocalization with paroxetine.},
  author={P Meoni and Frank C. Tortella and Norman G. Bowery},
  journal={British journal of pharmacology},
  year={1997},
  volume={120 7},
  pages={1255-62}
}
1. The distribution and some pharmacological properties of centrally located dextromethorphan high-affinity binding sites were investigated by in vitro autoradiography. 2. Sodium chloride (50 mM) induced a 7 to 12 fold increase in dextromethorphan binding to rat brain in all areas tested. The effect of sodium was concentration-dependent with a higher dose… CONTINUE READING