An autonomous metabolic role for Spen

  title={An autonomous metabolic role for Spen},
  author={Kelsey E. Hazegh and Travis Nemkov and Angelo D'Alessandro and John D Diller and Jenifer Monks and James L McManaman and Kenneth L. Jones and Kirk C Hansen and T{\^a}nia Reis},
  booktitle={PLoS genetics},
Preventing obesity requires a precise balance between deposition into and mobilization from fat stores, but regulatory mechanisms are incompletely understood. Drosophila Split ends (Spen) is the founding member of a conserved family of RNA-binding proteins involved in transcriptional regulation and frequently mutated in human cancers. We find that… CONTINUE READING