An automated voxelized dosimetry tool for radionuclide therapy based on serial quantitative SPECT/CT imaging.

@article{Jackson2013AnAV,
  title={An automated voxelized dosimetry tool for radionuclide therapy based on serial quantitative SPECT/CT imaging.},
  author={Price A. Jackson and Jean-Mathieu Beauregard and Michael S Hofman and Tomas Kron and Annette Hogg and Rodney J Hicks},
  journal={Medical physics},
  year={2013},
  volume={40 11},
  pages={
          112503
        }
}
PURPOSE To create an accurate map of the distribution of radiation dose deposition in healthy and target tissues during radionuclide therapy. METHODS Serial quantitative SPECT∕CT images were acquired at 4, 24, and 72 h for 28 (177)Lu-octreotate peptide receptor radionuclide therapy (PRRT) administrations in 17 patients with advanced neuroendocrine tumors. Deformable image registration was combined with an in-house programming algorithm to interpolate pharmacokinetic uptake and clearance at a… CONTINUE READING
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