An automated in vitro dermal absorption procedure: III. In vivo and in vitro comparison with the insect repellent N,N-diethyl-m-toluamide in mouse, rat, guinea pig, pig, human and tissue-cultured skin.

@article{Moody1993AnAI,
  title={An automated in vitro dermal absorption procedure: III. In vivo and in vitro comparison with the insect repellent N,N-diethyl-m-toluamide in mouse, rat, guinea pig, pig, human and tissue-cultured skin.},
  author={Richard P Moody and Bruno Nadeau},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={1993},
  volume={7 2},
  pages={167-76}
}
Cross-species in vitro dermal absorption tests were conducted with the (14)C-ring-labelled insect repellent, DEET (N,N-diethyl-m-toluamide), dissolved in acetone and applied to skin sections (0.5 mm) from a dermatome at a dose rate of about 30 mug/cm(2). Skin permeation was determined using an automated in vitro dermal absorption procedure, and was calculated from the percentage recovery of (14)C-activity in the receiver solution. Listed in decreasing order, the total percentage of in vitro… CONTINUE READING