An automated high throughput liquid chromatography-mass spectrometry process to assess the metabolic stability of drug candidates.

@article{Drexler2007AnAH,
  title={An automated high throughput liquid chromatography-mass spectrometry process to assess the metabolic stability of drug candidates.},
  author={Dieter M. Drexler and James V Belcastro and Kenneth E Dickinson and Kurt J Edinger and Serhiy Y Hnatyshyn and Jonathan L Josephs and Robert A. Langish and Colleen A Mcnaney and Kenneth S. Santone and Petia A. Shipkova and Adrienne A. Tymiak and Tatyana A Zvyaga and Mark Sanders},
  journal={Assay and drug development technologies},
  year={2007},
  volume={5 2},
  pages={247-64}
}
An automated high throughput process, termed the MetFast assay, is described to assess in vitro the general microsomal cytochrome P450 beta-nicotinamide adenine dinucleotide phosphate-mediated first-pass metabolic stability of potential drug candidates as a utility for pharmaceutical profiling. Utilizing robotic protocols with a multiprobe liquid handler… CONTINUE READING