An autoimmune disease prevented by anti-retroviral drugs

  title={An autoimmune disease prevented by anti-retroviral drugs},
  author={Gabriele B. Beck-Engeser and Dan Eilat and Matthias R. Wabl},
Both Aicardi-Goutières syndrome, a Mendelian mimic of congenital infection, and the autoimmune disease systemic lupus erythematosus can result from mutations in the gene encoding the enzyme Trex1. In mice, the absence of Trex1 causes severe myocarditis. The enzyme is thought to degrade endogenous retroelements, thus linking them to autoimmune disease. However, inhibition of reverse transcription by the inhibitor zidovudine (AZT) did not ameliorate the disease, weakening the link to… CONTINUE READING
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