An autocrine or a paracrine role of adrenomedullin in modulating cardiac fibroblast growth.

@article{Tsuruda1999AnAO,
  title={An autocrine or a paracrine role of adrenomedullin in modulating cardiac fibroblast growth.},
  author={Toshihiro Tsuruda and Junzo Kato and Kazuo Kitamura and Masashi Kawamoto and Kenji Kuwasako and Tomohiko Imamura and Yasushi Koiwaya and Teppei Tsuji and Kenji Kangawa and Tanenao Eto},
  journal={Cardiovascular research},
  year={1999},
  volume={43 4},
  pages={
          958-67
        }
}
OBJECTIVE The aim of the present study was to determine the role of adrenomedullin (AM) in cardiac fibroblasts. METHODS The production and secretion of AM were examined in cultured neonatal rat cardiac fibroblasts, and the effects of AM on proliferation and protein synthesis of these cells were assessed by [3H]thymidine and [3H]phenylalanine incorporation, respectively. RESULTS Cultured cardiac fibroblasts secreted AM into the medium time-dependently at a rate of 20.3 +/- 3.0 fmol/5 x 10(4… CONTINUE READING
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