An autocrine/paracrine role of human decidual relaxin. I. Interstitial collagenase (matrix metalloproteinase-1) and tissue plasminogen activator.

@article{Qin1997AnAR,
  title={An autocrine/paracrine role of human decidual relaxin. I. Interstitial collagenase (matrix metalloproteinase-1) and tissue plasminogen activator.},
  author={Xinyu Qin and Jermelina L Garibay-Tupas and Pong Kian Chua and L Cachola and Gillian D Bryant-Greenwood},
  journal={Biology of reproduction},
  year={1997},
  volume={56 4},
  pages={800-11}
}
Decidual and placental relaxins have been proposed as autocrine/ paracrine hormones in the remodeling of collagen in the amnion and chorion in the last weeks of pregnancy. The matrix metalloproteinase-1 (MMP-1) is a key enzyme in the degradation of the interstitial collagens which predominate in the fetal membranes. Distribution of the MMP-1 gene and of the MMP-1 protein was shown by in situ hybridization and immunolocalization, respectively, in amnion, chorion, and decidua collected from… CONTINUE READING