An atypical topoisomerase II from archaea with implications for meiotic recombination

@article{Bergerat1997AnAT,
  title={An atypical topoisomerase II from archaea with implications for meiotic recombination},
  author={Agn{\`e}s Bergerat and Bernard de Massy and Danielle Gadelle and P C Varoutas and Alain Nicolas and Patrick Forterre},
  journal={Nature},
  year={1997},
  volume={386},
  pages={414-417}
}
Type II topoisomerases help regulate DNA topology during transcription, replication and recombination by catalysing DNA strand transfer through transient double-stranded breaks1. All type II topoisomerases described so far are members of a single protein family2. We have cloned and sequenced the genes encoding the A and B subunits of topoisomerase II from the archaeon Sulfolobus shibatae. This enzyme is the first of a new family. It has no similarity with other type II topoisomerases, except… CONTINUE READING
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