An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites

@article{Dittrich2008AnAO,
  title={An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites},
  author={Sabine Dittrich and Sarah L Mitchell and Andrew M. Blagborough and Qi Wang and Ping Wang and P. F. Sims and J. E. Hyde},
  journal={Molecular Microbiology},
  year={2008},
  volume={67},
  pages={609 - 618}
}
Folate metabolism in malaria parasites is a long-standing, clinical target for chemotherapy and prophylaxis. However, despite determination of the complete genome sequence of the lethal species Plasmodium falciparum, the pathway of de novo folate biosynthesis remains incomplete, as no candidate gene for dihydroneopterin aldolase (DHNA) could be identified. This enzyme catalyses the third step in the well-characterized pathway of plants, bacteria, and those eukaryotic microorganisms capable of… CONTINUE READING